LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS
نویسندگان
چکیده
منابع مشابه
miR-135a promotes gastric cancer progression and resistance to oxaliplatin
Resistance to oxaliplatin (OXA)-based chemotherapy regimens continues to be a major cause of gastric cancer (GC) recurrence and metastasis. We analyzed GC samples and matched non-tumorous control stomach tissues from 280 patients and found that miR-135a was overexpressed in GC samples relative to control tissues. Tumors with high miR-135a expression were more likely to have aggressive character...
متن کاملDecreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
BACKGROUND The molecular mechanism between Helicobacter pylori (H. pylori) infection and gastric cancer remained largely unknown. In this study, we determined the role of miRNA in H. pylori induced gastric cancer. METHODS AND RESULTS We found that miR-204 was decreased in H. pylori positive tissues by qRT-PCR. Knockdown of miR-204 enhanced the invasion and proliferation ability of gastric can...
متن کاملmiR-181a-5p promotes the progression of gastric cancer via RASSF6-mediated MAPK signalling activation.
We previously discovered that Ras association domain family member 6 (RASSF6) was downregulated and predicted poor prognosis in GC patients. However, the mechanisms of the down regulation of RASSF6 in GC remained unclear. Increasing evidence indicates that dysregulation of microRNAs promotes the progression of cancer through the repression of tumour suppressors. Here, we identified miR-181a-5p ...
متن کاملmiR-19a Promotes Cell Growth and Tumorigenesis by Targeting SOCS1 in Gastric Cancer
Gastric cancer is the fourth most common cancer and the second leading cause of global cancer mortality (Jemal et al., 2011). Despite great progress in surgical technique, diagnostic method and new chemotherapy regimens, no effective targeting therapy is available for gastric cancer (Shi et al., 2010). Thus, understanding the molecular mechanism underlying gastric cancer is still needed. MicroR...
متن کاملE2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle
BACKGROUND Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F family member, was reported to associate with progression of several human cancers, however, its clinical significance and biological role in PTC remain unknown. METHODS E2F8 or miR-144 expression profiles in PTC tissues were ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging
سال: 2021
ISSN: 1945-4589
DOI: 10.18632/aging.202905